Catalogue Search | MBRL
هل أنت متأكد أنك تريد إزالة الكتاب من الرف؟
{{itemTitle}}
19
نتائج ل
"Miller, Kat"
صنف حسب:
I love the Jonas Brothers
Profiles the life and entertainment career of the successful young pop group the Jonas Brothers.
Book
I love Miley Cyrus
Highlights the life and accomplishments of the singer and actress Miley Cyrus, known for her role in the Disney Channel series \"Hannah Montana.\"
Book
Building wildlife resilience in disasters
The emerging role of Zoos Victoria and other conservation-based organisations in responding to emergencies was highlighted during the Australian summer bushfires in 2019-20. Working alongside partners in government and local communities, as well as research, wildlife, veterinary and non-government organisations, the experience and expertise of Zoos Victoria played a lead role in wildlife response, relief and recovery efforts.
Journal Article
I love Robert Pattinson
Profiles the life and career of film actor Robert Pattinson, best known for his work in the Harry Potter and Twilight films.
Book
Development and validation of an integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit
Anti-PD-1 and PD-L1 (collectively PD-[L]1) therapies are approved for many advanced solid tumors. Biomarkers beyond PD-L1 immunohistochemistry, microsatellite instability, and tumor mutation burden (TMB) may improve benefit prediction.
Using treatment data and genomic and transcriptomic tumor tissue profiling from an observational trial (NCT03061305), we developed Immunotherapy Response Score (IRS), a pan-tumor predictive model of PD-(L)1 benefit. IRS real-world progression free survival (rwPFS) and overall survival (OS) prediction was validated in an independent cohort of trial patients.
Here, by Cox modeling, we develop IRS-which combines TMB with CD274, PDCD1, ADAM12 and TOP2A quantitative expression-to predict pembrolizumab rwPFS (648 patients; 26 tumor types; IRS-High or -Low groups). In the 248 patient validation cohort (248 patients; 24 tumor types; non-pembrolizumab PD-[L]1 monotherapy treatment), median rwPFS and OS are significantly longer in IRS-High vs. IRS-Low patients (rwPFS adjusted hazard ratio [aHR] 0.52, p = 0.003; OS aHR 0.49, p = 0.005); TMB alone does not significantly predict PD-(L)1 rwPFS nor OS. In 146 patients treated with systemic therapy prior to pembrolizumab monotherapy, pembrolizumab rwPFS is only significantly longer than immediately preceding therapy rwPFS in IRS-High patients (interaction test p = 0.001). In propensity matched lung cancer patients treated with first-line pembrolizumab monotherapy or pembrolizumab+chemotherapy, monotherapy rwPFS is significantly shorter in IRS-Low patients, but is not significantly different in IRS-High patients. Across 24,463 molecularly-evaluable trial patients, 7.6% of patients outside of monotherapy PD-(L)1 approved tumor types are IRS-High/TMB-Low.
The validated, predictive, pan-tumor IRS model can expand PD-(L)1 monotherapy benefit outside currently approved indications.
Journal Article
Building wildlife resilience in disasters
The emerging role of Zoos Victoria1 and other conservation-based organisations in responding to emergencies was highlighted during the Australian summer bushfires in 2019-20. Working alongside partners in government and local communities, as well as research, wildlife, veterinary and non-government organisations, the experience and expertise of Zoos Victoria played a lead role in wildlife response, relief and recovery efforts.
Journal Article
I love Kristen Stewart
Profiles the life and career of film actor Kristen Stewart, best known for her work in the Twilight movies.
Book
The small museum toolkit.: (Leadership, mission, and governance)
Small museums face the same challenges as large museums on a tighter budget and with fewer resources. Navigating these obstacles requires strong leadership and effective governance. The creation and use of planning documents and a clear mission and vision are essential to pursuing the long-term health of an organization. This book features concise, grounded approaches to finding and articulating the mission and vision of a small museum. Because a few tools have been invaluable to small museum leaders, the book also highlights the MAP and CAP assessment process, accreditation, and provides an overview of the StEPs program.
eBook